TY - JOUR
T1 - Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease
AU - Sampedro, Frederic
AU - Martinez-Horta, Saul
AU - Horta, Andrea
AU - Grothe, Michael J.
AU - Labrador-Espinosa, Miguel A.
AU - Jesús, Silvia
AU - Adarmes-Gómez, A.D
AU - Carrillo, Fátima
AU - Puig-Davi, Arnau
AU - Roldan-Lora, Florinda
AU - Aguilar Barberà, Miquel
AU - Pastor, Pau
AU - Escalante Arroyo, Sonia
AU - Solano Vila, Berta
AU - Cots-Foraster, Anna
AU - Ruiz-Martínez, Javier
AU - Carrillo Padilla, Francisco
AU - Pueyo-Morlans, Mercedes
AU - Gonzalez-Aramburu, Isabel
AU - Infante-Ceberio, Jon
AU - Hernandez-Vara, Jorge
AU - Fàbregues-Boixar i Nebot, Oriol de
AU - Deus Fonticoba, María Teresa de
AU - Ávila, Asunción
AU - Martínez-Castrillo, Juan Carlos
AU - Bejr-Kasem Marco, Helena
AU - Campolongo, Antonia
AU - Pascual-Sedano, Berta María
AU - Martínez-Martín, Pablo
AU - Santos García, Diego
AU - Mir, Pablo
AU - García Ruiz, Pedro J
AU - Kulisevsky, Jaime
PY - 2022
Y1 - 2022
N2 - Background and purpose: Reduced facial expression of emotions is a very frequent symptom of Parkinson's disease (PD) and has been considered part of the motor features of the disease. However, the neural correlates of hypomimia and the relationship between hypomimia and other non-motor symptoms of PD are poorly understood. Methods: The clinical and structural brain correlates of hypomimia were studied. For this purpose, cross-sectional data from the COPPADIS study database were used. Age, disease duration, levodopa equivalent daily dose, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), severity of apathy and depression and global cognitive status were collected. At the imaging level, analyses based on gray matter volume and cortical thickness were used. Results: After controlling for multiple confounding variables such as age or disease duration, the severity of hypomimia was shown to be indissociable from the UPDRS-III speech and bradykinesia items and was significantly related to the severity of apathy (β = 0.595; p < 0.0001). At the level of neural correlates, hypomimia was related to motor regions brodmann area 8 (BA 8) and to multiple fronto-temporo-parietal regions involved in the decoding, recognition and production of facial expression of emotions. Conclusion: Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge.
AB - Background and purpose: Reduced facial expression of emotions is a very frequent symptom of Parkinson's disease (PD) and has been considered part of the motor features of the disease. However, the neural correlates of hypomimia and the relationship between hypomimia and other non-motor symptoms of PD are poorly understood. Methods: The clinical and structural brain correlates of hypomimia were studied. For this purpose, cross-sectional data from the COPPADIS study database were used. Age, disease duration, levodopa equivalent daily dose, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), severity of apathy and depression and global cognitive status were collected. At the imaging level, analyses based on gray matter volume and cortical thickness were used. Results: After controlling for multiple confounding variables such as age or disease duration, the severity of hypomimia was shown to be indissociable from the UPDRS-III speech and bradykinesia items and was significantly related to the severity of apathy (β = 0.595; p < 0.0001). At the level of neural correlates, hypomimia was related to motor regions brodmann area 8 (BA 8) and to multiple fronto-temporo-parietal regions involved in the decoding, recognition and production of facial expression of emotions. Conclusion: Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge.
KW - Hypomimia
KW - Neural
KW - Neuroimage
KW - Non-motor symptoms
KW - Parkinson's disease
U2 - 10.1111/ene.15513
DO - 10.1111/ene.15513
M3 - Article
C2 - 35852918
SN - 1468-1331
JO - European Journal of Neurology
JF - European Journal of Neurology
ER -