Clinical and serological findings associated with the expression of ITGAL, PRF1, and CD70 in systemic lupus erythematosus

Eva Balada, Jesús Castro-Marrero, Lledó Felip, Josep Ordi-Ros, Miquel Vilardell-Tarrés

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13 Citations (Scopus)

Abstract

We determined the expression of Integrin alpha L chain (ITGAL), Perforin 1 (PRF1), and CD70 and studied the associations with laboratory and clinical parameters. CD4+ T cells were isolated from 35 SLE patients and 30 healthy controls. The transcript levels of ITGAL, PRF1, and CD70 were quantified by real-time reverse-transcription polymerase chain reaction (RT-PCR). The SLE patients had significantly elevated transcript levels of ITGAL (18.61±22.17 vs. 7.33±9.17, p=0.042), PRF1 (21.67±26.34 vs. 10.67±11.65, p=0.039), and CD70 (1.45±1.63 vs. 0.67± 0.28, p=0.011). Patients with anti-microsomal and/or anti-thyroglobulin antibodies showed high levels of ITGAL (33.41±30.14 vs. 13.58±16.43, p=0.044; and 34.01±27.66 vs. 11.90±16.17, p=0.007, respectively). No association was seen either for the typical antibodies of SLE or for the disease activity. Although ITGAL, PRF1, and CD70 are overexpressed in SLE CD4+ T cells, their expression is not linked to the typical clinical and serological parameters associated with the disease. The role that ITGAL may playin autoimmune thyroiditis deserves further investigation. © Clinical and Experimental Rheumatology 2014.
Original languageEnglish
Pages (from-to)113-116
JournalClinical and Experimental Rheumatology
Volume32
Issue number1
Publication statusPublished - 25 Feb 2014

Keywords

  • CD70
  • Epigenetics
  • Integrin Alpha l chain
  • Lupus
  • Perforin 1

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