Class IV mammalian alcohol dehydrogenase. Structural data of the rat stomach enzyme reveal a new class well separated from those already characterized

Xavier Parés, Alberto Moreno, Ella Cederlund, Jan Olov Höög, Jans Jörnvall

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Abstract

The stomach form of alcohol dehydrogenase has been structurally evaluated by peptide analysis covering six separate regions of the rat enzyme. Overall, this new structure diners widely (32-40% residue differences) from the structures of three classes of alcohol dehydrogenase characterized before from the same species. Consequently, this novel enzyme constitutes a true fourth class of mammalian alcohol dehydrogenase. In particular, differences are extensive also towards class II, although enzymatic and physicochemical properties initially suggested overall similarities with class II. The new structure establishes the presence of one further alcohol dehydrogenase mammalian gene, extends the enzyme family derived from repeated gene duplications, and confirms tissue-specific expressions. © 1990.
Original languageEnglish
Pages (from-to)115-118
JournalFEBS Letters
Volume277
Issue number1-2
DOIs
Publication statusPublished - 17 Dec 1990

Keywords

  • Alcohol dehydrogenase
  • Amino acid sequence
  • Enzyme class
  • Gene duplication
  • Homology

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