Circulating levels of microRNA 423-5p are associated with 90 day mortality in cardiogenic shock

Toni Jäntti, Heli Segersvärd, Heli Tolppanen, Tuukka Tarvasmäki, Johan Lassus, Yvan Devaux, Mélanie Vausort, Kari Pulkki, Alessandro Sionis, Antoni Bayes-Genis, Ilkka Tikkanen, Päivi Lakkisto, Veli Pekka Harjola

Research output: Contribution to journalArticleResearch

5 Citations (Scopus)

Abstract

© 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. Aims: The role of microRNAs has not been studied in cardiogenic shock. We examined the potential role of miR-423-5p level to predict mortality and associations of miR-423-5p with prognostic markers in cardiogenic shock. Methods and results: We conducted a prospective multinational observational study enrolling consecutive cardiogenic shock patients. Blood samples were available for 179 patients at baseline to determine levels of miR-423-5p and other biomarkers. Patients were treated according to local practice. Main outcome was 90 day all-cause mortality. Median miR-423-5p level was significantly higher in 90 day non-survivors [median 0.008 arbitrary units (AU) (interquartile range 0.003–0.017) vs. 0.004 AU (0.002–0.009), P = 0.003]. miR-423-5p level above median was associated with higher lactate (median 3.7 vs. 2.4 mmol/L, P = 0.001) and alanine aminotransferase levels (median 68 vs. 35 IU/L, P < 0.001) as well as lower cardiac index (1.8 vs. 2.4, P = 0.04) and estimated glomerular filtration rate (56 vs. 70 mL/min/1.73 m 2 , P = 0.002). In Cox regression analysis, miR-423-5p level above median was associated with 90 day all-cause mortality independently of established risk factors of cardiogenic shock [adjusted hazard ratio 1.9 (95% confidence interval 1.2–3.2), P = 0.01]. Conclusions: In cardiogenic shock patients, above median level of miR-423-5p at baseline is associated with markers of hypoperfusion and seems to independently predict 90 day all-cause mortality.
Original languageEnglish
Pages (from-to)98-102
JournalESC heart failure
Volume6
DOIs
Publication statusPublished - 1 Feb 2019

Keywords

  • Acute coronary syndrome
  • Cardiogenic shock
  • Mortality
  • Prognosis
  • miR-423-5p
  • microRNA

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