Circulating endothelial progenitor cells after kidney transplantation

María José Soler, Ofelia María Martínez-Estrada, Josep Maria Puig-Marí, Didac Marco-Feliu, Anna Oliveras, Joan Vila, Marisa Mir, Antonia Orfila, Senén Vilaró, Josep Lloveras

    Research output: Contribution to journalArticleResearchpeer-review

    25 Citations (Scopus)

    Abstract

    Circulating endothelial progenitor cells (EPCs) promote vascular repair and maintain integrity of the endothelial monolayer. Reduced EPCs number has been associated with endothelial dysfunction in various cardiovascular diseases. Cardiovascular disease risk is higher in renal transplant patients (RT) than the general population. We studied EPCs number and proliferation in RT, and examined the association with other cardiovascular risk factors such as reduced glomerular filtration rate (GFR) and LDL cholesterol. EPCs concentration was determined in 94 RT and 39 control subjects (C) by flow cytometry. EPCs proliferation was also studied after 7 days in culture. EPCs concentration was significantly reduced in RT versus C (median 33.5 [5-177] vs. 53 [9-257] EPCs/105 PMN cells, p = 0.006). EPCs proliferation was also reduced in RT versus C (mean ± SD; 372.7 ± 229.3 vs. 539.8 ± 291.3 EPCs × field, p = 0.003). In multiple regression analysis, GFR, HDL, LDL and body weight were independent predictors of EPCs concentration in RT (r 2 = 0.25, p < 0.001). EPCs number is reduced in RT, particularly in patients with reduced GFR. Moreover, EPCs from RT studied in vitro, showed reduced proliferation, which is a sign of functional impairment. These alterations may be involved in increased cardiovascular risk of RT. Copyright © Blackwell Munksgaard 2005.
    Original languageEnglish
    Pages (from-to)2154-2159
    JournalAmerican Journal of Transplantation
    Volume5
    Issue number9
    DOIs
    Publication statusPublished - 1 Sep 2005

    Keywords

    • Cardiovascular risk
    • Endothelial progenitor cells
    • Kidney transplantation

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