Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases

Marta Ferran, Ester R. Romeu, Catalina Rincón, Marc Sagristà, Ana M. Giménez Arnau, Antonio Celada, Ramon M. Pujol, Péter Holló, Hajnalka Jókai, Luis F. Santamaria-Babí

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T-cell-mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T-cell-mediated skin diseases. © 2013 John Wiley & Sons A/S.
Original languageEnglish
Pages (from-to)439-442
JournalExperimental Dermatology
Volume22
Issue number7
DOIs
Publication statusPublished - 1 Jul 2013

Keywords

  • Associated antigen
  • Biomarker
  • Cutaneous lymphocyte
  • Skin-homing
  • T lymphocyte

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