TY - JOUR
T1 - Cilostazol and outcome in outpatients with peripheral artery disease
AU - Perez, Paulina
AU - Esteban, Carlos
AU - Sauquillo, Joan Carles
AU - Yeste, Monserrat
AU - Manzano, Luis
AU - Mujal, Abel
AU - Jiménez Caballero, Pedro Enrique
AU - Aguilar, Eduardo
AU - Sánchez Muñoz-Torrero, Juan Francisco
AU - Monreal, Manuel
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background Cilostazol increases the walking distance in patients with intermittent claudication, but there is scarce evidence of any effect on the risk for subsequent ischemic events, bleeding or death. Patients and Methods We used data from the FRENA Registry to compare the clinical outcome in stable outpatients with intermittent claudication, according to the use of cilostazol. Results As of January 2013, 1,317 patients with intermittent claudication were recruited in FRENA, of whom 191 (14.5%) received cilostazol. Over a mean follow-up of 18 months, 39 patients developed myocardial infarction, 23 ischemic stroke, 20 underwent limb amputation, 15 had major bleeding and 70 died. There were no significant differences in the rate of subsequent ischemic events, major bleeding or death between patients receiving or not receiving cilostazol. On multivariate analysis, the use of cilostazol had no influence on the risk for subsequent myocardial infarction (hazard ratio [HR]: 0.97; 95% CI: 0.33-20.8), ischemic stroke (HR: 1.46; 95% CI: 0.48-4.43), limb amputation (HR: 0.34; 95% CI: 0.04-20.6), major bleeding (HR: 1.52; 95% CI: 0.33-7.09) or death (HR: 0.90; 95% CI: 0.40-20.0). Conclusions In stable outpatients with intermittent claudication, the use of cilostazol was not associated with increased rates of subsequent ischemic events, major bleeding or death. © 2014 Elsevier Ltd.
AB - Background Cilostazol increases the walking distance in patients with intermittent claudication, but there is scarce evidence of any effect on the risk for subsequent ischemic events, bleeding or death. Patients and Methods We used data from the FRENA Registry to compare the clinical outcome in stable outpatients with intermittent claudication, according to the use of cilostazol. Results As of January 2013, 1,317 patients with intermittent claudication were recruited in FRENA, of whom 191 (14.5%) received cilostazol. Over a mean follow-up of 18 months, 39 patients developed myocardial infarction, 23 ischemic stroke, 20 underwent limb amputation, 15 had major bleeding and 70 died. There were no significant differences in the rate of subsequent ischemic events, major bleeding or death between patients receiving or not receiving cilostazol. On multivariate analysis, the use of cilostazol had no influence on the risk for subsequent myocardial infarction (hazard ratio [HR]: 0.97; 95% CI: 0.33-20.8), ischemic stroke (HR: 1.46; 95% CI: 0.48-4.43), limb amputation (HR: 0.34; 95% CI: 0.04-20.6), major bleeding (HR: 1.52; 95% CI: 0.33-7.09) or death (HR: 0.90; 95% CI: 0.40-20.0). Conclusions In stable outpatients with intermittent claudication, the use of cilostazol was not associated with increased rates of subsequent ischemic events, major bleeding or death. © 2014 Elsevier Ltd.
KW - Cilostazol
KW - Intermittent claudication
KW - Outcome
KW - Safety
U2 - 10.1016/j.thromres.2014.05.040
DO - 10.1016/j.thromres.2014.05.040
M3 - Article
VL - 134
SP - 331
EP - 335
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 2
ER -