Chronic urticaria: Prospective ethiologic study and autoimmune syndrome significance

Ana M. Giménez-Arnau, Marta Ferrer, Hans Jürger Peter, Marcus Maurer, Ramón M. Pujol

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9 Citations (Scopus)


Introduction. Chronic urticaria is defined as a skin eruption consisting of weals, which lasts for over six weeks. Its association with different autoimmune diseases and with the presence of circulating autoantibodies has been described. Objectives. To support the concept of chronic autoimmune urticaria. Material and methods. This was a prospective study that included patients with chronic urticaria. The etiologic screening protocol included the determination of autoantibodies in serum and the autologous serum test. The functional activity of the serum was compared with the in vitro basophil histamine release results. A retrospective ELISA study was carried out on the presence of IgE-antiperoxidase in selected patients. Results. Of the 274 cases of urticaria recorded, 166 corresponded to chronic urticaria with no physical trigger. An etiological or related factor was present in 42.6% of the chronic urticarias. 36.9% of the autologous serum tests performed were positive. A good level of correlation was seen between the positive and negative results of the autologous serum test and the ability of the serum itself to induce histamine release by the basophil. Patients with associated autoimmune phenomena were reviewed, and antiperoxidase IgE antibodies were found in two patients. The use of immunomodulator treatment was justified in some patients because of the positive result of the autologous serum test. Conclusions. Our results support the concept of chronic urticaria with autoimmune disease.
Original languageEnglish
Pages (from-to)560-566
JournalActas Dermo-Sifiliograficas
Issue number9
Publication statusPublished - 1 Jan 2004


  • Autoimmunity
  • Autologous serum test
  • Basophil histamine release test
  • FcεRIα IgE
  • IgE antiperoxidase
  • Urticaria

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