Chronic stress reduces serum but not liver metallothionein response to acute stress

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    Abstract

    Rats subjected to chronic immobilization stress showed a reduced serum metallothionein (MT) response to acute immobilization stress compared to nonchronically stressed rats. In contrast, liver MT response to acute immobilization stress was not influenced by previous chronic immobilization stress. These results suggest that serum MT levels are likely under endocrine regulation and that they do not reflect directly liver MT levels. Instead it appears that both MT pools are regulated differently. The fact that liver MT is resistant to adaptation to chronic stress may be related to its physiological function. © 1993.
    Original languageEnglish
    Pages (from-to)1-5
    JournalChemico-Biological Interactions
    Volume88
    DOIs
    Publication statusPublished - 1 Jan 1993

    Keywords

    • Acute stress
    • Chronic stress
    • Serum and liver metallothionein

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