Chronic stress induced changes in LH secretion: The contribution of anorexia associated to stress

O. Martí, A. Gavaldà, J. Martí, M. Gil, M. Giralt, A. López-Calderón, A. Armario

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Abstract

The effects of chronic intermittent immobilization (IMO) on serum LH levels of adult male rats were studied. Chronic IMO (2 h daily for 13 days) did not alter basal LH levels, but abolished the LH response to acute stressors (IMO and tailshock). The inhibition of LH caused by acute exposure to IMO for 4 or 18 h was similar in control and chronic IMO rats. Also the LH response to exogenous LHRH administration was normal in chronically stressed rats. When a group of rats eating the same amount of food as that eaten by immobilized rats was introduced (pair-fed), an inhibition of LH response to acute stressors quite similar to that found in chronic IMO rats was observed. These data indicate that chronic stress-induced inhibition of LH release caused by short-term exposure to acute stressors was located above the pituitary and was mainly due to anorexia accompanying daily exposure to the stressor. © 1993.
Original languageEnglish
Pages (from-to)1187-1194
JournalLife Sciences
Volume52
DOIs
Publication statusPublished - 1 Jan 1993

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