Chronic neuropathy with IgM antiganglioside antibodies: Lack of long term response to rituximab

R. Rojas-García, E. Gallardo, I. De Andrés, N. De Luna, C. Juarez, P. Sánchez, Isabel Illa

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Abstract

Two patients with chronic motor neuropathy, high antiganglioside antibody (AGA) titers, and a declining response to IV immunoglobulins were treated with rituximab at a standard dose. The drug was well tolerated and effectively eliminated peripheral B cells (CD20+), but AGA titers continued significantly high. No clinical improvement was detected during the 1-year follow-up.
Original languageEnglish
Pages (from-to)1814-1816
JournalNeurology
Volume61
Issue number12
DOIs
Publication statusPublished - 23 Dec 2003

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