Chromosome studies in oocytes and zygotes from an IVF programme

Anna Veiga, Gloria Calderoèn, Josep Santalo, Pedro N. Barri, Joseè Egozcue

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    Chromosome studies have been carried out in 117 oocytes, 17 one-cell zygotes and four, two- to four-cell zygotes in our IVF programme. Three apparently unfertilized oocytes were, in fact, diploid zygotes. Two of 14 apparently polyspermic zygotes were also diploid. One zygote with four pronuclei was pentaploid. This indicates that pronuclei can either be confused with other cytoplasmic structures, like vacuoles, or be eliminated. Endoreduplkation was observed in one tetraploid, apparently polyspermic zygote, and in one two-cell degenerated zygote. The incidence of aneuploidy in unfertilized oocytes, taken as twice the level of hyperhaploidy, was 15.47percnt;. Five oocytes showed fragmented metaphase II chromosomes (4.3%). The incidence of unreduced oocytes, due to a lack of extrusion of the first polar body, was 6.87percnt;. Thus the total number of potentially aneuploid, polyploid or non-viable zygotes due to chromosome aberrations in the oocyte was 26.5%. © 1987 IRL Press Ltd.
    Original languageEnglish
    Pages (from-to)425-430
    JournalHuman Reproduction
    Issue number5
    Publication statusPublished - 1 Jan 1987


    • Chromosome studies
    • IVF programme

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