Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients - A possible evidence for chromosome instability

Leonardo Barrios, María Rosa Caballín, Rosa Mirò, Carme Fuster, Georgina Berrozpe, Antoni Subías, Xavier Batlle, Josep Egozcue

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48 Citations (Scopus)

Abstract

We describe the presence of a high frequency of spontaneous chromosome aberrations in lymphocytes from six untreated patients with Hodgkin's disease. The characteristics of the chromosome abnormalities observed suggest the existence of a certain degree of chromosome instability in these cases, that could be a predisposing factor for the development of malignancies. © 1988 Springer-Verlag.
Original languageEnglish
Pages (from-to)320-324
JournalHuman Genetics
Volume78
DOIs
Publication statusPublished - 1 Apr 1988

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