Chromosome abnormalities in peripheral blood lymphocytes from Cebus apella (Cebidae, Platyrrhini) after X-ray irradiation

A. Borrell, M. Ponsà, J. Egozcue, A. Rubio, M. Garcia

    Research output: Contribution to journalArticleResearchpeer-review

    10 Citations (Scopus)

    Abstract

    In this paper, we describe the results of a qualitative and quantitative study of chromosomal reorganizations observed in X-irradiated (1Gy and 2Gy) and cultured lymphocytes from Cebus apella. A total of 646 breakpoints have been detected, identified and localized in the ideogram of the species. The breakpoint distribution along chromosomes, p and q arms, and bands is not random. Chromosomes 11, 12 and chromosome arms 1p, 12p, 13p, 15p, 11q, and 12q are significantly more affected than expected, while chromosome 19 and chromosome arm 19q are less affected. Terminal regions of chromosome arms accumulate a higher number of breakpoints than the rest of the chromosome (37.82%). A high percentage (93.66%) of breakpoints is found in G negative bands.
    Original languageEnglish
    Pages (from-to)65-76
    JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
    Volume401
    DOIs
    Publication statusPublished - 5 Jun 1998

    Keywords

    • Cebus
    • Chromosome breakpoints
    • Primates
    • X-irradiated

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