Recent advances in the knowledge of the molecular biology of paediatric sarcomas, especially the characterisation of chromosomal translocations associated specifically with particular types of cancer, have established bases for the introduction of new diagnostic tools. This article reviews the main chromosomal translocations associated with paediatric tumours, and summarises their molecular characteristics regarding their oncogenic capabilities, possible usefulness as a differential diagnostic tools and possible correlation with clinical parameters.
|Translated title of the contribution||Chromosomal translocations in soft tissue sarcomas: From molecular biology to clinical application|
|Journal||Anales de Pediatria|
|Publication status||Published - Feb 2012|