Chromosomal instability in breast cancer patients

Leonardo Barrios, M. R. Caballín, Rosa Miró, Carme Fuster, Ferràn Guedea, Antoni Subias, Josep Egozcue

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)


We have carried out cytogenetic studies, using the G-banding technique, in peripheral blood lymphocytes of 10 patients affected by breast carcinoma. The frequency of aberrant metaphases (7.36%) is significantly different from that of our laboratory controls (3.76% of aberrant metaphases) but not from that detected in patients suffering from bladder cancer (10.64%) and Hodgkin's disease (11.03%), two conditions that have previously been described as chromosomally unstable. Our results suggest that breast carcinoma patients show a degree of chromosomal instability that could be related to a predisposition to neoplastic disease. © 1991 Springer-Verlag.
Original languageEnglish
Pages (from-to)39-41
JournalHuman Genetics
Issue number1
Publication statusPublished - 1 Nov 1991


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