Choroiditis and meningitis in experimental murine infection with Listeria monocytogenes

N. Prats, V. Briones, M. M. Blanco, J. Altimira, J. A. Ramos, L. Domínguez, A. Marco

    Research output: Contribution to journalArticleResearchpeer-review

    45 Citations (Scopus)

    Abstract

    In a study of central nervous system involvement in experimental listeriosis 27 Swiss CD1 mice were inoculated subcutaneously with Listeria monocytogenes. Systemic infection developed, as shown by the isolation of Listeria monocytogenes and histopathological lesions in the spleen and liver. In the central nervous system a mixed inflammatory infiltration in the ventricular system, especially in the choroid plexus, and leptomeningitis were the most relevant lesions. Inflammatory lesions were associated with the presence of Listeria monocytogenes, as demonstrated by a positive anti-Listeria monocytogenes immunoperoxidase reaction within phagocytic cells. It is suggested that choroiditis and meningitis developed as a consequence of hematogenous dissemination of Listeria monocytogenes within mononuclear phagocytes and penetration of these cells into the ventricular system through the choroid plexus. © 1992 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.
    Original languageEnglish
    Pages (from-to)744-747
    JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
    Volume11
    Issue number8
    DOIs
    Publication statusPublished - 1 Aug 1992

    Fingerprint

    Dive into the research topics of 'Choroiditis and meningitis in experimental murine infection with Listeria monocytogenes'. Together they form a unique fingerprint.

    Cite this