Children often present with infantile spasms after herpetic encephalitis

Gemma Aznar Laín, Georges Dellatolas, Monika Eisermann, Nathalie Boddaert, Catherine Chiron, Christine Bulteau, José P. Monteiro, Isabelle An, Jean Michel Pédespan, Claude Cancès, Sylvianne Peudenier, Marie Anne Barthez, Mathieu Milh, Georges Dorfmuller, Bénédicte Héron, Rima Nabbout, David Grevent, Olivier Dulac

    Research output: Contribution to journalArticleResearchpeer-review

    5 Citations (Scopus)


    Purpose To determine what epilepsy types occur after herpetic encephalitis and what are the determinant factors for subsequent infantile spasms. Methods We analyzed retrospectively the clinical history of 22 patients, referred to Necker and Saint Vincent de Paul Hospitals (Paris) through the French pediatric epilepsy network from March 1986 to April 2010 and who developed epilepsy some months after herpetic encephalitis. We focused on seizure semiology with video-electroencephalography (EEG) recording, and on neuroradiology and epilepsy follow-up. Key Findings Fourteen patients developed pharmacoresistant spasms, and eight developed focal epilepsy, but none had both. The patients who developed spasms were more frequently younger than 30 months at age of onset of epilepsy and had herpetic encephalitis earlier (mean 10.6 months of age) than those who developed focal epilepsy (mean 59.7 and 39.6 months, respectively). Epilepsy follow-up was similar in both groups (8.5 and 11 years, respectively). We found 26 affected cerebral areas; none alone was related to the development of epileptic spasms. Significance Risk factors to develop epileptic spasms were to have had herpetic encephalitis early (mean 10 months); to be significantly younger at onset of epilepsy (mean 22.1 months); and to have cerebral lesions involving the insula, the hippocampus, and the temporal pole. © Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.
    Original languageEnglish
    Pages (from-to)1571-1576
    Issue number9
    Publication statusPublished - 1 Sep 2013


    • Brain maturation
    • Herpetic encephalitis
    • Infantile spasms
    • Insula


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