Chemical probes for the recognition of cannabinoid receptors in native systems

Lidia Martín-Couce, Mar Martín-Fontecha, O'Scar Palomares, Leyre Mestre, Arnau Cordomí, Miriam Hernangomez, Sara Palma, Leonardo Pardo, Carmen Guaza, María L. Lõpez-Rodríguez, Silvia Ortega-Gutiérrez

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Receptors made visible: The described biotin-tagged small-molecule probes with excellent affinities for the CB1 and CB2 cannabinoid receptors (CB1R and CB2R) enable direct visualization of these receptors in native cellular systems, including neurons (see picture), microglia, and immune cells. This method could overcome some of the limitations of current methodologies and may help to dissect the complexity of the endogenous cannabinoid system. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)6896-6899
JournalAngewandte Chemie - International Edition
Volume51
DOIs
Publication statusPublished - 9 Jul 2012

Keywords

  • bioorganic chemistry
  • cannabinoid ligands
  • chemical probes
  • membrane proteins
  • protein models

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