Abstract
© 2016 Future Medicine Ltd. Aim: To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. Methods: 95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. Results: The isolates showed a high diversity (IOD 0.964) with a predominance of some profiles (ST37-Phialdelphia, ST23-Philadelphia and ST1-OLDA). All regions had predominant sequence types (STs) that differed between regions, and only 3% of STs were shared between the three regions. Conclusion: L. pneumophila clinical isolates from Catalonia presented a high diversity and can be used in epidemiological surveillance studies. The heterogeneous predominance of STs between European regions suggested a relationship between geographical distribution and virulence of some STs.
Original language | English |
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Pages (from-to) | 865-875 |
Journal | Future Microbiology |
Volume | 11 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Jul 2016 |
Keywords
- clinical isolates
- Legionella
- monoclonal antibody
- sequence-based typing