Characterization of unrelated clinical Legionella pneumophila isolates in Catalonia by monoclonal subgrouping and sequence-based typing

Marian Garcia-Nuñez, Sara Quero, Maria Lluisa Pedro-Botet, Irene Barrabeig, Josep Avarez, Irene Campoy, Maria Rosa Sala, Noemí Parraga-Niño, Sofia Minguell, Joan Caylà, Lourdes Mateu, Miquel Sabria

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2 Citations (Scopus)

Abstract

© 2016 Future Medicine Ltd. Aim: To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. Methods: 95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. Results: The isolates showed a high diversity (IOD 0.964) with a predominance of some profiles (ST37-Phialdelphia, ST23-Philadelphia and ST1-OLDA). All regions had predominant sequence types (STs) that differed between regions, and only 3% of STs were shared between the three regions. Conclusion: L. pneumophila clinical isolates from Catalonia presented a high diversity and can be used in epidemiological surveillance studies. The heterogeneous predominance of STs between European regions suggested a relationship between geographical distribution and virulence of some STs.
Original languageEnglish
Pages (from-to)865-875
JournalFuture Microbiology
Volume11
Issue number7
DOIs
Publication statusPublished - 1 Jul 2016

Keywords

  • clinical isolates
  • Legionella
  • monoclonal antibody
  • sequence-based typing

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