Characterization of a Supported Liquid Membrane Based System for the Enantioseparation of SR-Propranolol by N-Hexadecyl-L-hydroxyproline

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Abstract

A supported liquid membrane (SLM) containing the chiral selector N-hexadecyl-L-hydroxyproline (HHP) was characterized for the enantioseparation of a β-blocking drug. SR-propranolol was the target racemic mixture to be resolved by the membrane separation system. The different affinity shown by the selected carrier, HHP, for the two propranolol enantiomers produced a discrimination of their transport through this SLM. We investigated the influence of various chemical parameters involved in that system, such as the acidity of feed and receiving phases, as well as the carrier concentration in the membrane. Valuable knowledge on the transport mechanisms within this system was thus attained.
Original languageEnglish
Pages (from-to)431-447
JournalSep. sci. technol.
Volume39
Issue number2
Publication statusPublished - 16 Mar 2004

Keywords

  • β-Blocking drugs
  • Characterization
  • Enantioseparation
  • SLM

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