Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome

Judit Sánchez-Castro; Víctor Marco-Betés; Xavier Gómez-Arbonés; Leonor Arenillas; David Valcarcel; Teresa Vallespí; Dolors Costa; Benet Nomdedeu; María José Jimenez; Isabel Granada; Javier Grau; María T. Ardanaz; Javier de la Serna; Félix Carbonell; José Cervera; Adriana Sierra; Elisa Luño; Carlos J. Cervero; José Falantes; María J. Calasanz; José R. González-Porrás; Alicia Bailén; M. Luz Amigo; Guillermo Sanz; Francesc Solé

doi:10.1016/j.leukres.2013.04.010

Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome

Judit Sánchez-Castro, Víctor Marco-Betés, Xavier Gómez-Arbonés, Leonor Arenillas, David Valcarcel, Teresa Vallespí, Dolors Costa, Benet Nomdedeu, María José Jimenez, Isabel Granada, Javier Grau, María T. Ardanaz, Javier de la Serna, Félix Carbonell, José Cervera, Adriana Sierra, Elisa Luño, Carlos J. Cervero, José Falantes, María J. CalasanzJosé R. González-Porrás, Alicia Bailén, M. Luz Amigo, Guillermo Sanz, Francesc Solé

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group.This study assessed the impact on overall survival (OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved.The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes. © 2013 Elsevier Ltd.

Original language	English
Pages (from-to)	769-776
Journal	Leukemia Research
Volume	37
Issue number	7
DOIs	https://doi.org/10.1016/j.leukres.2013.04.010
Publication status	Published - 1 Jul 2013

Keywords

Chromosome 17
Cytogenetic
Myelodysplastic syndromes
Prognosis

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Sánchez-Castro, J., Marco-Betés, V., Gómez-Arbonés, X., Arenillas, L., Valcarcel, D., Vallespí, T., Costa, D., Nomdedeu, B., Jimenez, M. J., Granada, I., Grau, J., Ardanaz, M. T., de la Serna, J., Carbonell, F., Cervera, J., Sierra, A., Luño, E., Cervero, C. J., Falantes, J., ... Solé, F. (2013). Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome. Leukemia Research, 37(7), 769-776. https://doi.org/10.1016/j.leukres.2013.04.010

@article{89f1a7bf1ecb4aa48f127bf65ec72f06,

title = "Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome",

abstract = "The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group.This study assessed the impact on overall survival (OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved.The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes. {\textcopyright} 2013 Elsevier Ltd.",

keywords = "Chromosome 17, Cytogenetic, Myelodysplastic syndromes, Prognosis",

author = "Judit S{\'a}nchez-Castro and V{\'i}ctor Marco-Bet{\'e}s and Xavier G{\'o}mez-Arbon{\'e}s and Leonor Arenillas and David Valcarcel and Teresa Vallesp{\'i} and Dolors Costa and Benet Nomdedeu and Jimenez, {Mar{\'i}a Jos{\'e}} and Isabel Granada and Javier Grau and Ardanaz, {Mar{\'i}a T.} and {de la Serna}, Javier and F{\'e}lix Carbonell and Jos{\'e} Cervera and Adriana Sierra and Elisa Lu{\~n}o and Cervero, {Carlos J.} and Jos{\'e} Falantes and Calasanz, {Mar{\'i}a J.} and Gonz{\'a}lez-Porr{\'a}s, {Jos{\'e} R.} and Alicia Bail{\'e}n and Amigo, {M. Luz} and Guillermo Sanz and Francesc Sol{\'e}",

year = "2013",

month = jul,

day = "1",

doi = "10.1016/j.leukres.2013.04.010",

language = "English",

volume = "37",

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journal = "Leukemia Research",

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Sánchez-Castro, J, Marco-Betés, V, Gómez-Arbonés, X, Arenillas, L, Valcarcel, D, Vallespí, T, Costa, D, Nomdedeu, B, Jimenez, MJ, Granada, I, Grau, J, Ardanaz, MT, de la Serna, J, Carbonell, F, Cervera, J, Sierra, A, Luño, E, Cervero, CJ, Falantes, J, Calasanz, MJ, González-Porrás, JR, Bailén, A, Amigo, ML, Sanz, G & Solé, F 2013, 'Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome', Leukemia Research, vol. 37, no. 7, pp. 769-776. https://doi.org/10.1016/j.leukres.2013.04.010

TY - JOUR

T1 - Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome

AU - Sánchez-Castro, Judit

AU - Marco-Betés, Víctor

AU - Gómez-Arbonés, Xavier

AU - Arenillas, Leonor

AU - Valcarcel, David

AU - Vallespí, Teresa

AU - Costa, Dolors

AU - Nomdedeu, Benet

AU - Jimenez, María José

AU - Granada, Isabel

AU - Grau, Javier

AU - Ardanaz, María T.

AU - de la Serna, Javier

AU - Carbonell, Félix

AU - Cervera, José

AU - Sierra, Adriana

AU - Luño, Elisa

AU - Cervero, Carlos J.

AU - Falantes, José

AU - Calasanz, María J.

AU - González-Porrás, José R.

AU - Bailén, Alicia

AU - Amigo, M. Luz

AU - Sanz, Guillermo

AU - Solé, Francesc

PY - 2013/7/1

Y1 - 2013/7/1

N2 - The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group.This study assessed the impact on overall survival (OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved.The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes. © 2013 Elsevier Ltd.

AB - The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group.This study assessed the impact on overall survival (OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved.The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes. © 2013 Elsevier Ltd.

KW - Chromosome 17

KW - Cytogenetic

KW - Myelodysplastic syndromes

KW - Prognosis

U2 - 10.1016/j.leukres.2013.04.010

DO - 10.1016/j.leukres.2013.04.010

M3 - Article

SN - 0145-2126

VL - 37

SP - 769

EP - 776

JO - Leukemia Research

JF - Leukemia Research

IS - 7

ER -

Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome

Abstract

Keywords

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