Changes in the proportions of histone H1° subtypes in brain cortical neurons

B. Piña; P. Suau

doi:10.1016/0014-5793(87)81328-5

Changes in the proportions of histone H1° subtypes in brain cortical neurons

B. Piña, P. Suau

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Abstract

Histone H1° is found in tissues with little or no cellular proliferation and has been shown to accumulate during cellular terminal differentiation. Two subtypes of H1°, H1°a and H1°b, are present in any tissue where the protein has been detected. We report here the first evidence of an age-dependent change in the proportions of H1° subtypes. In rat cerebral cortex neurons the proportion of H1°a rises from 44% of total H1° at birth to about 80% at day 300. These results show that terminally differentiated neurons synthesize and exchange H1° at a significant rate. © 1987.

Original language	English
Pages (from-to)	161-164
Journal	FEBS Letters
Volume	210
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(87)81328-5
Publication status	Published - 5 Jan 1987

Keywords

(Brain cortical neuron)
Aging
Histone H1°
Histone H1° subtype
Histone subtype proportion

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10.1016/0014-5793(87)81328-5

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title = "Changes in the proportions of histone H1° subtypes in brain cortical neurons",

abstract = "Histone H1° is found in tissues with little or no cellular proliferation and has been shown to accumulate during cellular terminal differentiation. Two subtypes of H1°, H1°a and H1°b, are present in any tissue where the protein has been detected. We report here the first evidence of an age-dependent change in the proportions of H1° subtypes. In rat cerebral cortex neurons the proportion of H1°a rises from 44% of total H1° at birth to about 80% at day 300. These results show that terminally differentiated neurons synthesize and exchange H1° at a significant rate. {\textcopyright} 1987.",

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AU - Suau, P.

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N2 - Histone H1° is found in tissues with little or no cellular proliferation and has been shown to accumulate during cellular terminal differentiation. Two subtypes of H1°, H1°a and H1°b, are present in any tissue where the protein has been detected. We report here the first evidence of an age-dependent change in the proportions of H1° subtypes. In rat cerebral cortex neurons the proportion of H1°a rises from 44% of total H1° at birth to about 80% at day 300. These results show that terminally differentiated neurons synthesize and exchange H1° at a significant rate. © 1987.

AB - Histone H1° is found in tissues with little or no cellular proliferation and has been shown to accumulate during cellular terminal differentiation. Two subtypes of H1°, H1°a and H1°b, are present in any tissue where the protein has been detected. We report here the first evidence of an age-dependent change in the proportions of H1° subtypes. In rat cerebral cortex neurons the proportion of H1°a rises from 44% of total H1° at birth to about 80% at day 300. These results show that terminally differentiated neurons synthesize and exchange H1° at a significant rate. © 1987.

KW - (Brain cortical neuron)

KW - Aging

KW - Histone H1°

KW - Histone H1° subtype

KW - Histone subtype proportion

U2 - 10.1016/0014-5793(87)81328-5

DO - 10.1016/0014-5793(87)81328-5

M3 - Article

SN - 0014-5793

VL - 210

SP - 161

EP - 164

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Changes in the proportions of histone H1° subtypes in brain cortical neurons

Abstract

Keywords

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