Changes in Principal Caregiver Mood Affects the Mood of the Parkinson's Disease Patient :: The Vicious Cycle of Illness

D. Santos-García; T. De Deus Fonticoba; C. Cores Bartolomé; M.J. Feal Painceiras; M.C. Íñiguez-Alvarado; Iago García Díaz; S. Jesús; M.T. Buongiorno; L. Planellas; Marina Cosgaya; J. García Caldentey; N. Caballol; I. Legarda; Jorge Hernández-Vara; I. Cabo; L. López Manzanares; I. González Aramburu; M.A. Ávila Rivera; V. Gómez Mayordomo; V. Nogueira; Víctor Puente; J. Dotor García-Soto; C. Borrué; B. Solano Vila; M. Álvarez Sauco; L. Vela; S. Escalante; E. Cubo; F. Carrillo Padilla; J.C. Martínez Castrillo; P. Sánchez Alonso; M.G. Alonso Losada; N. López Ariztegui; I. Gastón; Jaime Kulisevsky; M. Menéndez González; M. Seijo; J. Rúiz Martínez; C. Valero; M. Kurtis; J. González Ardura; R. Alonso Redondo; C. Ordás; L.M. López Díaz; D. McAfee; P. Martinez-Martin; P. Mir

doi:10.3233/JPD-225014

Changes in Principal Caregiver Mood Affects the Mood of the Parkinson's Disease Patient : The Vicious Cycle of Illness

D. Santos-García, T. De Deus Fonticoba, C. Cores Bartolomé, M.J. Feal Painceiras, M.C. Íñiguez-Alvarado, Iago García Díaz, S. Jesús, M.T. Buongiorno, L. Planellas, Marina Cosgaya, J. García Caldentey, N. Caballol, I. Legarda, Jorge Hernández-Vara, I. Cabo, L. López Manzanares, I. González Aramburu, M.A. Ávila Rivera, V. Gómez Mayordomo, V. NogueiraVíctor Puente, J. Dotor García-Soto, C. Borrué, B. Solano Vila, M. Álvarez Sauco, L. Vela, S. Escalante, E. Cubo, F. Carrillo Padilla, J.C. Martínez Castrillo, P. Sánchez Alonso, M.G. Alonso Losada, N. López Ariztegui, I. Gastón, Jaime Kulisevsky, M. Menéndez González, M. Seijo, J. Rúiz Martínez, C. Valero, M. Kurtis, J. González Ardura, R. Alonso Redondo, C. Ordás, L.M. López Díaz, D. McAfee, P. Martinez-Martin, P. Mir

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Although many studies have analyzed what factors contribute to caregiver burden in Parkinson's disease (PD), there is currently no knowledge about how the status of the caregiver could impact the patient. Objective: The aim of this study was to analyze how the change in the caregiver's status influences PD patients. PD patients and their caregivers who were recruited from January/2016 to November/2017 from 35 centers in Spain from the COPPADIS cohort were included in the study (V0). They were evaluated again at 2-year follow-up (V2). Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), and EUROHIS-QOL 8-item index (EUROHIS-QOL8) at V0 and V2. Multivariate models were used to analyze the impact of the change from V0 to V2 () on the caregiver's status over the change in the patient's status. BDI-II and EUROHIS-QOL8 in the caregiver predicted BDI-II (= 0.32; p < 0.0001; R2 = 0.71) and EUROHIS-QOL8 (= 0.39; p < 0.0001; R2 = 0.68) in the patient, respectively. Variables related to the caregiver were not associated with changes in the patient's health-related QoL (PDQ-39 [39-item Parkinson's disease Questionnaire]) or autonomy for activities of daily-living (ADLS [Schwab & England Activities of Daily Living Scale]). The change in the caregiver's mood and global QoL was associated with the change in the patient's mood and global QoL, respectively, independently of other variables of the disease influencing both patient's aspects. Based on this finding, it could be of great importance to detect depression in the principal caregiver of a patient and act on it as earlier as possible.

Original language	English
Pages (from-to)	0219-231
Number of pages	13
Journal	Journal of Parkinson's Disease
Volume	13
Issue number	2
DOIs	https://doi.org/10.3233/JPD-225014
Publication status	Published - 2023

Keywords

pCaregiver
arkinson’s disease
Longitudinal
Mood
Quality of life

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10.3233/JPD-225014

https://ddd.uab.cat/record/303472

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Santos-García, D., De Deus Fonticoba, T., Cores Bartolomé, C., Feal Painceiras, M. J., Íñiguez-Alvarado, M. C., García Díaz, I., Jesús, S., Buongiorno, M. T., Planellas, L., Cosgaya, M., García Caldentey, J., Caballol, N., Legarda, I., Hernández-Vara, J., Cabo, I., López Manzanares, L., González Aramburu, I., Ávila Rivera, M. A., Gómez Mayordomo, V., ... Mir, P. (2023). Changes in Principal Caregiver Mood Affects the Mood of the Parkinson's Disease Patient : The Vicious Cycle of Illness. Journal of Parkinson's Disease, 13(2), 0219-231. https://doi.org/10.3233/JPD-225014

@article{1d4428a8e16c4314b15b26afebb00314,

title = "Changes in Principal Caregiver Mood Affects the Mood of the Parkinson's Disease Patient :: The Vicious Cycle of Illness",

abstract = "Although many studies have analyzed what factors contribute to caregiver burden in Parkinson's disease (PD), there is currently no knowledge about how the status of the caregiver could impact the patient. Objective: The aim of this study was to analyze how the change in the caregiver's status influences PD patients. PD patients and their caregivers who were recruited from January/2016 to November/2017 from 35 centers in Spain from the COPPADIS cohort were included in the study (V0). They were evaluated again at 2-year follow-up (V2). Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), and EUROHIS-QOL 8-item index (EUROHIS-QOL8) at V0 and V2. Multivariate models were used to analyze the impact of the change from V0 to V2 () on the caregiver's status over the change in the patient's status. BDI-II and EUROHIS-QOL8 in the caregiver predicted BDI-II (= 0.32; p < 0.0001; R2 = 0.71) and EUROHIS-QOL8 (= 0.39; p < 0.0001; R2 = 0.68) in the patient, respectively. Variables related to the caregiver were not associated with changes in the patient's health-related QoL (PDQ-39 [39-item Parkinson's disease Questionnaire]) or autonomy for activities of daily-living (ADLS [Schwab & England Activities of Daily Living Scale]). The change in the caregiver's mood and global QoL was associated with the change in the patient's mood and global QoL, respectively, independently of other variables of the disease influencing both patient's aspects. Based on this finding, it could be of great importance to detect depression in the principal caregiver of a patient and act on it as earlier as possible.",

keywords = "pCaregiver, arkinson{\textquoteright}s disease, Longitudinal, Mood, Quality of life",

author = "D. Santos-Garc{\'i}a and {De Deus Fonticoba}, T. and {Cores Bartolom{\'e}}, C. and {Feal Painceiras}, M.J. and M.C. {\'I}{\~n}iguez-Alvarado and {Garc{\'i}a D{\'i}az}, Iago and S. Jes{\'u}s and M.T. Buongiorno and L. Planellas and Marina Cosgaya and {Garc{\'i}a Caldentey}, J. and N. Caballol and I. Legarda and Jorge Hern{\'a}ndez-Vara and I. Cabo and {L{\'o}pez Manzanares}, L. and {Gonz{\'a}lez Aramburu}, I. and {{\'A}vila Rivera}, M.A. and {G{\'o}mez Mayordomo}, V. and V. Nogueira and V{\'i}ctor Puente and {Dotor Garc{\'i}a-Soto}, J. and C. Borru{\'e} and {Solano Vila}, B. and {{\'A}lvarez Sauco}, M. and L. Vela and S. Escalante and E. Cubo and {Carrillo Padilla}, F. and {Mart{\'i}nez Castrillo}, J.C. and {S{\'a}nchez Alonso}, P. and {Alonso Losada}, M.G. and {L{\'o}pez Ariztegui}, N. and I. Gast{\'o}n and Jaime Kulisevsky and {Men{\'e}ndez Gonz{\'a}lez}, M. and M. Seijo and {R{\'u}iz Mart{\'i}nez}, J. and C. Valero and M. Kurtis and {Gonz{\'a}lez Ardura}, J. and {Alonso Redondo}, R. and C. Ord{\'a}s and {L{\'o}pez D{\'i}az}, L.M. and D. McAfee and P. Martinez-Martin and P. Mir",

year = "2023",

doi = "10.3233/JPD-225014",

language = "English",

volume = "13",

pages = "0219--231",

journal = "Journal of Parkinson's Disease",

issn = "1877-7171",

number = "2",

}

Santos-García, D, De Deus Fonticoba, T, Cores Bartolomé, C, Feal Painceiras, MJ, Íñiguez-Alvarado, MC, García Díaz, I, Jesús, S, Buongiorno, MT, Planellas, L, Cosgaya, M, García Caldentey, J, Caballol, N, Legarda, I, Hernández-Vara, J, Cabo, I, López Manzanares, L, González Aramburu, I, Ávila Rivera, MA, Gómez Mayordomo, V, Nogueira, V, Puente, V, Dotor García-Soto, J, Borrué, C, Solano Vila, B, Álvarez Sauco, M, Vela, L, Escalante, S, Cubo, E, Carrillo Padilla, F, Martínez Castrillo, JC, Sánchez Alonso, P, Alonso Losada, MG, López Ariztegui, N, Gastón, I, Kulisevsky, J, Menéndez González, M, Seijo, M, Rúiz Martínez, J, Valero, C, Kurtis, M, González Ardura, J, Alonso Redondo, R, Ordás, C, López Díaz, LM, McAfee, D, Martinez-Martin, P & Mir, P 2023, 'Changes in Principal Caregiver Mood Affects the Mood of the Parkinson's Disease Patient : The Vicious Cycle of Illness', Journal of Parkinson's Disease, vol. 13, no. 2, pp. 0219-231. https://doi.org/10.3233/JPD-225014

TY - JOUR

T1 - Changes in Principal Caregiver Mood Affects the Mood of the Parkinson's Disease Patient :

T2 - The Vicious Cycle of Illness

AU - Santos-García, D.

AU - De Deus Fonticoba, T.

AU - Cores Bartolomé, C.

AU - Feal Painceiras, M.J.

AU - Íñiguez-Alvarado, M.C.

AU - García Díaz, Iago

AU - Jesús, S.

AU - Buongiorno, M.T.

AU - Planellas, L.

AU - Cosgaya, Marina

AU - García Caldentey, J.

AU - Caballol, N.

AU - Legarda, I.

AU - Hernández-Vara, Jorge

AU - Cabo, I.

AU - López Manzanares, L.

AU - González Aramburu, I.

AU - Ávila Rivera, M.A.

AU - Gómez Mayordomo, V.

AU - Nogueira, V.

AU - Puente, Víctor

AU - Dotor García-Soto, J.

AU - Borrué, C.

AU - Solano Vila, B.

AU - Álvarez Sauco, M.

AU - Vela, L.

AU - Escalante, S.

AU - Cubo, E.

AU - Carrillo Padilla, F.

AU - Martínez Castrillo, J.C.

AU - Sánchez Alonso, P.

AU - Alonso Losada, M.G.

AU - López Ariztegui, N.

AU - Gastón, I.

AU - Kulisevsky, Jaime

AU - Menéndez González, M.

AU - Seijo, M.

AU - Rúiz Martínez, J.

AU - Valero, C.

AU - Kurtis, M.

AU - González Ardura, J.

AU - Alonso Redondo, R.

AU - Ordás, C.

AU - López Díaz, L.M.

AU - McAfee, D.

AU - Martinez-Martin, P.

AU - Mir, P.

PY - 2023

Y1 - 2023

N2 - Although many studies have analyzed what factors contribute to caregiver burden in Parkinson's disease (PD), there is currently no knowledge about how the status of the caregiver could impact the patient. Objective: The aim of this study was to analyze how the change in the caregiver's status influences PD patients. PD patients and their caregivers who were recruited from January/2016 to November/2017 from 35 centers in Spain from the COPPADIS cohort were included in the study (V0). They were evaluated again at 2-year follow-up (V2). Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), and EUROHIS-QOL 8-item index (EUROHIS-QOL8) at V0 and V2. Multivariate models were used to analyze the impact of the change from V0 to V2 () on the caregiver's status over the change in the patient's status. BDI-II and EUROHIS-QOL8 in the caregiver predicted BDI-II (= 0.32; p < 0.0001; R2 = 0.71) and EUROHIS-QOL8 (= 0.39; p < 0.0001; R2 = 0.68) in the patient, respectively. Variables related to the caregiver were not associated with changes in the patient's health-related QoL (PDQ-39 [39-item Parkinson's disease Questionnaire]) or autonomy for activities of daily-living (ADLS [Schwab & England Activities of Daily Living Scale]). The change in the caregiver's mood and global QoL was associated with the change in the patient's mood and global QoL, respectively, independently of other variables of the disease influencing both patient's aspects. Based on this finding, it could be of great importance to detect depression in the principal caregiver of a patient and act on it as earlier as possible.

AB - Although many studies have analyzed what factors contribute to caregiver burden in Parkinson's disease (PD), there is currently no knowledge about how the status of the caregiver could impact the patient. Objective: The aim of this study was to analyze how the change in the caregiver's status influences PD patients. PD patients and their caregivers who were recruited from January/2016 to November/2017 from 35 centers in Spain from the COPPADIS cohort were included in the study (V0). They were evaluated again at 2-year follow-up (V2). Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), and EUROHIS-QOL 8-item index (EUROHIS-QOL8) at V0 and V2. Multivariate models were used to analyze the impact of the change from V0 to V2 () on the caregiver's status over the change in the patient's status. BDI-II and EUROHIS-QOL8 in the caregiver predicted BDI-II (= 0.32; p < 0.0001; R2 = 0.71) and EUROHIS-QOL8 (= 0.39; p < 0.0001; R2 = 0.68) in the patient, respectively. Variables related to the caregiver were not associated with changes in the patient's health-related QoL (PDQ-39 [39-item Parkinson's disease Questionnaire]) or autonomy for activities of daily-living (ADLS [Schwab & England Activities of Daily Living Scale]). The change in the caregiver's mood and global QoL was associated with the change in the patient's mood and global QoL, respectively, independently of other variables of the disease influencing both patient's aspects. Based on this finding, it could be of great importance to detect depression in the principal caregiver of a patient and act on it as earlier as possible.

KW - pCaregiver

KW - arkinson’s disease

KW - Longitudinal

KW - Mood

KW - Quality of life

U2 - 10.3233/JPD-225014

DO - 10.3233/JPD-225014

M3 - Article

C2 - 36683517

SN - 1877-7171

VL - 13

SP - 219

EP - 231

JO - Journal of Parkinson's Disease

JF - Journal of Parkinson's Disease

IS - 2

ER -

Changes in Principal Caregiver Mood Affects the Mood of the Parkinson's Disease Patient : The Vicious Cycle of Illness

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Keywords

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