TY - JOUR
T1 - Changes in CD4 + T cells subsets in patients with alcohol-related cirrhosis
AU - Zuluaga Blanco, Yenny Paola
AU - Zurera Egea, Coral
AU - Fuster, Daniel
AU - Hernandez-Rubio, Anna
AU - Teniente Serra, Aina
AU - Martínez Cáceres, Eva María
AU - Muga, Roberto
PY - 2025/1/5
Y1 - 2025/1/5
N2 - Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4 + subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients without evidence of liver disease were the control group (CG). We analyzed naïve, memory, TEMRA, Th1, Th2, Th17, early activated, and late activated subsets. During the follow-up, TEMRA T cells were increased (1.2 ± 1.1% vs. 2.1 ± 1.1%, p = 0.03) in AC-patients (n = 5) and Th17 cells were decreased (14.1 ± 4.3% vs. 12.3 ± 6.4%, p = 0.03) in the CG (n = 22). Late activated cells were associated with a decrease in memory cells in both the groups. This association was stronger in AC-patients (r = − 0.90, p = 0.04). The proportion of memory cells was correlated with an increased of Th1/Th2/Th17 cells in the CG (r = 0.70, r = 0.68, r = 0.63; p < 0.01, respectively), whereas in AC-patients was correlated with a decrease in Th17 cells (r = − 0.90, p = 0.03). AC-patients showed an increase in the proportion of TEMRA T cells, loss of heterogeneity and decreased CD4 + differentiation.
AB - Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4 + subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients without evidence of liver disease were the control group (CG). We analyzed naïve, memory, TEMRA, Th1, Th2, Th17, early activated, and late activated subsets. During the follow-up, TEMRA T cells were increased (1.2 ± 1.1% vs. 2.1 ± 1.1%, p = 0.03) in AC-patients (n = 5) and Th17 cells were decreased (14.1 ± 4.3% vs. 12.3 ± 6.4%, p = 0.03) in the CG (n = 22). Late activated cells were associated with a decrease in memory cells in both the groups. This association was stronger in AC-patients (r = − 0.90, p = 0.04). The proportion of memory cells was correlated with an increased of Th1/Th2/Th17 cells in the CG (r = 0.70, r = 0.68, r = 0.63; p < 0.01, respectively), whereas in AC-patients was correlated with a decrease in Th17 cells (r = − 0.90, p = 0.03). AC-patients showed an increase in the proportion of TEMRA T cells, loss of heterogeneity and decreased CD4 + differentiation.
KW - T cell differentiation
KW - T cell subsets
KW - Adaptive immunity
KW - Alcohol use disorder
KW - Alcohol-related cirrhosis
UR - http://www.scopus.com/inward/record.url?scp=85214120171&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/1ea078ed-5e35-3808-871a-96ddcb56cdb0/
U2 - 10.1007/s10238-024-01548-0
DO - 10.1007/s10238-024-01548-0
M3 - Article
C2 - 39755990
SN - 0300-9130
VL - 25
JO - Research in Experimental Medicine
JF - Research in Experimental Medicine
IS - 1
ER -
