Changes in body mass index in girls with idiopathic central precocious puberty under gonadotropin-releasing hormone analogue therapy: The Spanish registry

Pablo Guerrero, Raquel Corripio, Leandro Soriano-Guillén, Francisco Javier Herrero, Ramón Cañete, Lidia Castro-Feijoó, Aránzazu Escribano, Rafael Espino, José Ignacio Labarta, Jesús Argente, José Juan Alcón Sáez, Francisco Javier Arroyo Díez, Cristina Azcona Sanjulián, Jesús Barreiro Conde, Lidia Blasco González, Mariona Bonet Alcaina, Victoria Borrás Pérez, Jordi Bosch Muñoz, Gloria Bueno Lozano, Paloma Cabanas RodriguezNuria Cabrinety Pérez, Gemma Carreras González, Luis Castaño González, Alicia Cepedano Dans, María Chueca Guindulain, Diego De Sotto Esteban, Ignacio Díez López, Pablo Fariña Guerrero, Concepción Fernández Ramos, Ángel Ferrández Longás, Elena Gallego Gómez, Julio Guerrero Fernández, Jesús González De Buitrago, Juan Pedro González Díaz, Ricardo Gracia Bouthelier, Antonio Gutiérrez Macías, José Luis Lechuga Campoy, Alfonso Lechuga Sancho, Luis López-Canti, Juan Pedro López Siguero, Gracia Mo Lou Francés, Gertrudis Martí Aromir, Jesús Martín Calama, Rosa Martín Ramos, María José Martínez Aedo Ollero, José María Martos Tello, Esteban Mayayo Dehesa, Raquel Monné Gelonch, María Teresa Muñoz Calvo, Marta Murillo Vallés, José Pastor Rosado, Jacobo Pérez Sánchez, Amparo Plasencia Couchoud, Manuel Pombo Arias, Jesús Pozo Román, Sofía Quinteiro González, Joaquín Ramírez Fernández, José Manuel Rial Rodríguez, Isolina Riaño Galán, Itxaso Rica Etxebarría, Dolores Rodríguez Arnao, Amparo Rodríguez Sánchez, Monserrat Roqueta Sureda, Purificación Ros Pérez, Rafael Ruiz Cano, Manuel Ruiz Echarri Zalaya, Luis Salamanca Fresno, Jaime Sánchez Del Pozo, Larisa Suárez Ortega, Rosangela Tomasini, Meritxell Torrabías Rodas, Diego Yeste Fernández, Rafael Yturriaga Matarranz

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

© 2016 S. Karger AG, Basel. Background: The influence of gonadotropin-releasing hormone analogue (GnRHa) treatment on body mass index (BMI) evolution in girls with idiopathic central precocious puberty (CPP) is unclear. Hence, we aimed to evaluate the effect of GnRHa treatment on BMI-standard deviation score (SDS) from diagnosis of idiopathic CPP until adult height. Methods: An observational study of girls diagnosed with CPP in Spain was carried out between January 2008 and December 2014. A computer program was designed to process clinical and biological data from patients treated in 55 departments of pediatric endocrinology throughout the country. The inclusion criteria were (1) girls diagnosed with CPP before 8 years of age; (2) born after 1992; (3) with a difference between bone and chronological age of at least 1 year, and (4) with a luteinizing hormone peak >7 U/l during luteinizing hormone-releasing hormone testing. The influence of GnRHa treatment on BMI-SDS evolution was analyzed. Results: Data from 333 girls (22.2% adopted) were evaluated. We report follow-up data at 6, 12, 24, 36, 48 and 60 months and adult height from 269, 232, 198, 153, 105, 56 and 49 girls, respectively. During treatment, there was an increase in BMI-SDS of 0.43 ± 1.17 (95% CI: 0.20-0.64). At adult height (n = 49), BMI-SDS was 1.51 ± 1.38, which was 0.60 ± 1.09 higher than at diagnosis (95% CI: 0.43-0.75). Conclusions: During treatment with GnRHa, girls experience a significant increase in BMI-SDS that persists after therapy is stopped and adult height has been reached.
Original languageEnglish
Pages (from-to)154-160
JournalHormone Research in Paediatrics
Volume86
Issue number3
DOIs
Publication statusPublished - 1 Oct 2016

Keywords

  • Body mass index
  • Central precocious puberty
  • Girls
  • Gonadotropin-releasing hormone analogue

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