© 2016 - IOS Press and the authors. All rights reserved. We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreasedAβ40 andAβ42. After treatment, focal symptomatology disappeared, andWMLand anti-Aβautoantibodies decreased. TheAPOEε4 allelewas overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.
|Journal||Journal of Alzheimer's Disease|
|Publication status||Published - 1 Jan 2016|
- cerebral amyloid angiopathy
- cerebrospinal fluid