Cerebellar posterior interpositus nucleus as an enhancer of classically conditioned eyelid responses in alert cats

A. Gruart, G. Guillazo-Blanch, R. Fernández-Mas, L. Jiménez-Díaz, J. M. Delgado-García

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Abstract

Cerebellar posterior interpositus neurons were recorded in cats during delayed and trace conditioning of eyeblinks. Type A neurons increased their firing in the time interval between conditioned and unconditioned stimulus presentations for both paradigms, while type B neurons decreased it. The discharge of different type A neurons recorded across successive conditioning sessions increased, with slopes of 0.061-0.078 spikes/s/trial. Both types of neurons modified their firing several trials in advance of the appearance of eyelid conditioned responses, but for each conditioned stimulus presentation their response started after conditioned response onset. Interpositus microstimulation evoked eyelid responses similar in amplitude and profiles to conditioned responses, and microinjection of muscimol decreased conditioned response amplitude. It is proposed that the interpositus nucleus is an enhancer, but not the initiator, of eyelid conditioned responses.
Original languageEnglish
Pages (from-to)2680-2690
JournalJournal of Neurophysiology
Volume84
Issue number5
Publication statusPublished - 29 Nov 2000

Fingerprint Dive into the research topics of 'Cerebellar posterior interpositus nucleus as an enhancer of classically conditioned eyelid responses in alert cats'. Together they form a unique fingerprint.

Cite this