Cerebellar neurometabolite abnormalities in pediatric attention/deficit hyperactivity disorder: A proton MR spectroscopic study

Juan Carlos Soliva, Ana Moreno, Jordi Fauquet, Anna Bielsa, Susanna Carmona, Juan Domingo Gispert, Mariana Rovira, Antoni Bulbena, Oscar Vilarroya

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25 Citations (Scopus)

Abstract

We designed a case-control proton magnetic resonance spectroscopic study comparing the cerebellar and prefrontal regions of a group of 17 ADHD (attention deficit/hyperactivity disorder) medicated children and a group of 17 control children matched for laterality, gender and age. As we had found decreased gray matter volume in the right prefrontal region and the left cerebellar hemisphere in a previous voxel-based morphometry study conducted on an independent ADHD sample, we tested the hypothesis that these regions should show neurometabolite abnormalities. MRI (magnetic resonance imaging) was performed with a 1.5 T system; spectral acquisition was performed with a single-voxel technique and a PRESS sequence. Two volumes of interest were selected in the right prefrontal region and the left cerebellar hemisphere. NAA (N-acetylaspartate), Cre (creatine), Cho (choline), MI (myo-inositol) and Glx (glutamate-glutamine) resonance intensities were absolutely quantified. In the left cerebellar hemisphere, ADHD children showed significant decreased MI and NAA absolute concentrations with high effect sizes (p = 0.004, ES = 1.184; p = 0.001, ES = 1.083). The diminished absolute concentration of the NAA could be related to a gray matter volume decrease in the same cerebellar region found in the previous voxel-based morphometry MRI study, while the reduced MI absolute concentration could express a decreased glial density. This is the first proton MR spectroscopic study examining the cerebellum and it provides additional support for the role of cerebellum in the ADHD neurobiology. © 2009 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)60-64
JournalNeuroscience Letters
Volume470
Issue number1
DOIs
Publication statusPublished - 5 Feb 2010

Keywords

  • ADHD
  • Cerebellum
  • MRI
  • Myo-inositol
  • N-acetylaspartate
  • Spectroscopy

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