TY - JOUR
T1 - Centromere splitting in bladder cancer
AU - Berrozpe, Georgina
AU - Caballin, Maria Rosa
AU - Miró, Rosa
AU - Gelabert, A.
AU - Egozcue, José
PY - 1990/7/1
Y1 - 1990/7/1
N2 - Cytogenetic studies on a bladder carcinoma, carried out using short time cultures, showed centromere splitting (CS) mainly affecting chromosomes 22, 13, 14, 21, 15, 20, 12, 7, 17, and 18. Clonal trisomies and monosomies were also detected. Our case is the first description of CS in bladder tumor cells. Our results suggest that CS is an early phenomenon in the karyotypic evolution of this case; it can be considered a primary, yet unspecific, chromosome change related to aneuploidy in bladder cancer. © 1990 Springer-Verlag.
AB - Cytogenetic studies on a bladder carcinoma, carried out using short time cultures, showed centromere splitting (CS) mainly affecting chromosomes 22, 13, 14, 21, 15, 20, 12, 7, 17, and 18. Clonal trisomies and monosomies were also detected. Our case is the first description of CS in bladder tumor cells. Our results suggest that CS is an early phenomenon in the karyotypic evolution of this case; it can be considered a primary, yet unspecific, chromosome change related to aneuploidy in bladder cancer. © 1990 Springer-Verlag.
U2 - https://doi.org/10.1007/BF00193193
DO - https://doi.org/10.1007/BF00193193
M3 - Article
SN - 0340-6717
VL - 85
SP - 184
EP - 186
JO - Human Genetics
JF - Human Genetics
IS - 2
ER -
