Centrality in the host-pathogen interactome is associated with pathogen fitness during infection

Núria Crua Asensio; Elisabet Munõz Giner; Natalia Sánchez De Groot; Marc Torrent Burgas

doi:10.1038/ncomms14092

Centrality in the host-pathogen interactome is associated with pathogen fitness during infection

Núria Crua Asensio, Elisabet Munõz Giner, Natalia Sánchez De Groot, Marc Torrent Burgas

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

53 Citations (Scopus)

Abstract

© 2017 The Author(s). To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly related to pathogen fitness during infection. Using Y. pestis as a model organism, we show that the centrality-lethality rule holds for pathogen fitness during infection but only when the host-pathogen interactome is considered. Our results suggest that the importance of pathogen proteins during infection is directly related to their number of interactions with the host. We also show that pathogen proteins causing an extensive rewiring of the host interactome have a higher impact in pathogen fitness during infection. Hence, we conclude that hubs in the host-pathogen interactome should be explored as promising targets for antimicrobial drug design.

Original language	English
Article number	14092
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms14092
Publication status	Published - 16 Jan 2017

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title = "Centrality in the host-pathogen interactome is associated with pathogen fitness during infection",

abstract = "{\textcopyright} 2017 The Author(s). To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly related to pathogen fitness during infection. Using Y. pestis as a model organism, we show that the centrality-lethality rule holds for pathogen fitness during infection but only when the host-pathogen interactome is considered. Our results suggest that the importance of pathogen proteins during infection is directly related to their number of interactions with the host. We also show that pathogen proteins causing an extensive rewiring of the host interactome have a higher impact in pathogen fitness during infection. Hence, we conclude that hubs in the host-pathogen interactome should be explored as promising targets for antimicrobial drug design.",

author = "{Crua Asensio}, N{\'u}ria and {Mun{\~o}z Giner}, Elisabet and {De Groot}, {Natalia S{\'a}nchez} and {Torrent Burgas}, Marc",

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T1 - Centrality in the host-pathogen interactome is associated with pathogen fitness during infection

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AU - Munõz Giner, Elisabet

AU - De Groot, Natalia Sánchez

AU - Torrent Burgas, Marc

PY - 2017/1/16

Y1 - 2017/1/16

N2 - © 2017 The Author(s). To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly related to pathogen fitness during infection. Using Y. pestis as a model organism, we show that the centrality-lethality rule holds for pathogen fitness during infection but only when the host-pathogen interactome is considered. Our results suggest that the importance of pathogen proteins during infection is directly related to their number of interactions with the host. We also show that pathogen proteins causing an extensive rewiring of the host interactome have a higher impact in pathogen fitness during infection. Hence, we conclude that hubs in the host-pathogen interactome should be explored as promising targets for antimicrobial drug design.

AB - © 2017 The Author(s). To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly related to pathogen fitness during infection. Using Y. pestis as a model organism, we show that the centrality-lethality rule holds for pathogen fitness during infection but only when the host-pathogen interactome is considered. Our results suggest that the importance of pathogen proteins during infection is directly related to their number of interactions with the host. We also show that pathogen proteins causing an extensive rewiring of the host interactome have a higher impact in pathogen fitness during infection. Hence, we conclude that hubs in the host-pathogen interactome should be explored as promising targets for antimicrobial drug design.

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JO - Nature Communications

JF - Nature Communications

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ER -

Centrality in the host-pathogen interactome is associated with pathogen fitness during infection

Abstract

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