Central blood pressure variability is increased in hypertensive patients with target organ damage

Alejandro de la Sierra, Julia Pareja, Sergi Yun, Eva Acosta, Francesco Aiello, Anna Oliveras, Susana Vázquez, Pedro Armario, Pedro Blanch, Cristina Sierra, Francesca Calero, Patricia Fernández-Llama

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    Abstract

    ©2018 Wiley Periodicals, Inc. We aimed to evaluate the association of aortic and brachial short-term blood pressure variability (BPV) with the presence of target organ damage (TOD) in hypertensive patients. One-hundred seventy-eight patients, aged 57 ± 12 years, 33% women were studied. TOD was defined by the presence of left ventricular hypertrophy on echocardiogram, microalbuminuria, reduced glomerular filtration rate, or increased aortic pulse wave velocity. Aortic and brachial BPV was assessed by 24-hour ambulatory BP monitoring (Mobil-O-Graph). TOD was present in 92 patients (51.7%). Compared to those without evidence of TOD, they had increased night-to-day ratios of systolic and diastolic BP (both aortic and brachial) and heart rate. They also had significant increased systolic BPV, as measured by both aortic and brachial daytime and 24-hours standard deviations and coefficients of variation, as well as for average real variability. Circadian patterns and short-term variability measures were very similar for aortic and brachial BP. We conclude that BPV is increased in hypertensive-related TOD. Aortic BPV does not add relevant information in comparison to brachial BPV.
    Original languageEnglish
    Pages (from-to)266-272
    JournalJournal of Clinical Hypertension
    Volume20
    Issue number2
    DOIs
    Publication statusPublished - 1 Feb 2018

    Keywords

    • ambulatory blood pressure monitoring
    • aortic blood pressure
    • blood pressure variability
    • central blood pressure
    • circadian blood pressure profile
    • organ damage

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    de la Sierra, A., Pareja, J., Yun, S., Acosta, E., Aiello, F., Oliveras, A., Vázquez, S., Armario, P., Blanch, P., Sierra, C., Calero, F., & Fernández-Llama, P. (2018). Central blood pressure variability is increased in hypertensive patients with target organ damage. Journal of Clinical Hypertension, 20(2), 266-272. https://doi.org/10.1111/jch.13172