Cellular immune responses in multiple sclerosis patients treated with interferon-beta

M. F. Bustamante; J. Rio; Z. Castro; A. Sánchez; X. Montalban; M. Comabella

doi:10.1111/cei.12016

Cellular immune responses in multiple sclerosis patients treated with interferon-beta

M. F. Bustamante, J. Rio, Z. Castro, A. Sánchez, X. Montalban, M. Comabella

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders. © 2012 British Society for Immunology.

Original language	English
Pages (from-to)	243-246
Journal	Clinical and Experimental Immunology
Volume	171
Issue number	3
DOIs	https://doi.org/10.1111/cei.12016
Publication status	Published - 1 Mar 2013

Keywords

Cellular immunity
Cytokines
Interferon-beta
Multiple sclerosis
Treatment response

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title = "Cellular immune responses in multiple sclerosis patients treated with interferon-beta",

abstract = "We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders. {\textcopyright} 2012 British Society for Immunology.",

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AU - Bustamante, M. F.

AU - Rio, J.

AU - Castro, Z.

AU - Sánchez, A.

AU - Montalban, X.

AU - Comabella, M.

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N2 - We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders. © 2012 British Society for Immunology.

AB - We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders. © 2012 British Society for Immunology.

KW - Cellular immunity

KW - Cytokines

KW - Interferon-beta

KW - Multiple sclerosis

KW - Treatment response

U2 - 10.1111/cei.12016

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M3 - Article

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SP - 243

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JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

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ER -

Cellular immune responses in multiple sclerosis patients treated with interferon-beta

Abstract

Keywords

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