Cellular immune responses in multiple sclerosis patients treated with interferon-beta

M. F. Bustamante, J. Rio, Z. Castro, A. Sánchez, X. Montalban, M. Comabella

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3 Citations (Scopus)

Abstract

We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders. © 2012 British Society for Immunology.
Original languageEnglish
Pages (from-to)243-246
JournalClinical and Experimental Immunology
Volume171
Issue number3
DOIs
Publication statusPublished - 1 Mar 2013

Keywords

  • Cellular immunity
  • Cytokines
  • Interferon-beta
  • Multiple sclerosis
  • Treatment response

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