Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids

Emma Puighermanal, Arnau Busquets-Garcia, Rafael Maldonado, Andrés Ozaita

Research output: Contribution to journalReview articleResearchpeer-review

73 Citations (Scopus)


Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system. © 2012 The Royal Society.
Original languageEnglish
Pages (from-to)3254-3263
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Issue number1607
Publication statusPublished - 5 Dec 2012


  • Cannabinoid receptor
  • CB1
  • Endocannabinoid system
  • Intracellular signalling
  • Memory


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