Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-oxidation of fatty acids

Ainara G. Cabodevilla, Laura Sánchez-Caballero, Eleni Nintou, Violeta G. Boiadjieva, Fernando Picatoste, Albert Gubern, Enrique Claro*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Abstract

Background: Cellular stress leading to cell death induces the formation of lipid droplets. Results: Nutrient deprivation induces LD biogenesis and mobilization, fueling fatty acid oxidation to sustain cell viability. Conclusion: β-Oxidation requires biogenesis and mobilization of LD. Significance: The role of LD in cell survival and β-oxidation might provide new potential targets for antitumor therapy.

Original languageEnglish
Pages (from-to)27777-27788
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
Publication statusPublished - 27 Sep 2013

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