Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-oxidation of fatty acids

Ainara G. Cabodevilla, Laura Sánchez-Caballero, Eleni Nintou, Violeta G. Boiadjieva, Fernando Picatoste, Albert Gubern, Enrique Claro

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65 Citations (Scopus)

Abstract

Background: Cellular stress leading to cell death induces the formation of lipid droplets. Results: Nutrient deprivation induces LD biogenesis and mobilization, fueling fatty acid oxidation to sustain cell viability. Conclusion: β-Oxidation requires biogenesis and mobilization of LD. Significance: The role of LD in cell survival and β-oxidation might provide new potential targets for antitumor therapy. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Original languageEnglish
Pages (from-to)27777-27788
JournalJournal of Biological Chemistry
Volume288
DOIs
Publication statusPublished - 27 Sep 2013

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    Cabodevilla, A. G., Sánchez-Caballero, L., Nintou, E., Boiadjieva, V. G., Picatoste, F., Gubern, A., & Claro, E. (2013). Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-oxidation of fatty acids. Journal of Biological Chemistry, 288, 27777-27788. https://doi.org/10.1074/jbc.M113.466656