Background: Cellular stress leading to cell death induces the formation of lipid droplets. Results: Nutrient deprivation induces LD biogenesis and mobilization, fueling fatty acid oxidation to sustain cell viability. Conclusion: β-Oxidation requires biogenesis and mobilization of LD. Significance: The role of LD in cell survival and β-oxidation might provide new potential targets for antitumor therapy. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
|Journal||Journal of Biological Chemistry|
|Publication status||Published - 27 Sep 2013|
Cabodevilla, A. G., Sánchez-Caballero, L., Nintou, E., Boiadjieva, V. G., Picatoste, F., Gubern, A., & Claro, E. (2013). Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-oxidation of fatty acids. Journal of Biological Chemistry, 288, 27777-27788. https://doi.org/10.1074/jbc.M113.466656