Ceftolozane/tazobactam for the treatment of XDR Pseudomonas aeruginosa infections

Laura Escolà-Vergé, Carles Pigrau, Ibai Los-Arcos, Ángel Arévalo, Belen Viñado, David Campany, Nieves Larrosa, Xavier Nuvials, Ricard Ferrer, Oscar Len, Benito Almirante

    Research output: Contribution to journalArticleResearchpeer-review

    17 Citations (Scopus)

    Abstract

    © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: The aim of this study was to evaluate the effectiveness of ceftolozane/tazobactam (C/T) for treating extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) infections, and to analyze whether high C/T dosing (2 g ceftolozane and 1 g tazobactam every 8 h) and infection source control have an impact on outcome. Methods: Retrospective study of all consecutive patients treated with C/T for XDR-PA infection at a tertiary referral hospital (November 2015–July 2017). Main clinical and microbiological variables were analyzed. Results: Thirty-eight patients were included. Median age was 59.5 years and Charlson Comorbidity Index was 3.5. Fourteen (36.8%) patients had respiratory tract infection, six (15.8%) soft tissue, and six (15.8%) urinary tract infection. Twenty-three (60.5%) received high-dose C/T and in 24 (63.2%) C/T was combined with other antibiotics. At completion of treatment, 33 (86.8%) patients showed clinical response. At 90 days of follow-up, 26 (68.4%) achieved clinical cure, and 12 (31.6%) had clinical failure because of persistent infection in one patient, death attributable to the XDR-PA infection in four, and clinical recurrence in seven. All-cause mortality was 5 (13.2%). Lower C/T MIC and adequate infection source control were the only variables significantly associated with clinical cure. Conclusions: C/T should be considered for treating XDR-PA infections, with infection source control being an important factor to avoid failure and resistance.
    Original languageEnglish
    Pages (from-to)461-468
    JournalInfection
    Volume46
    Issue number4
    DOIs
    Publication statusPublished - 1 Aug 2018

    Keywords

    • Ceftolozane/tazobactam
    • Extensively drug-resistant
    • Infection source control
    • Pseudomonas aeruginosa

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