CD4(+)CD45RO(+)CD49d(high) cells are involved in the pathogenesis of relapsing-remitting multiple sclerosis

X Montalban, EM Martinez-Caceres, MA Barrau, I Saez-Torres, L Brieva, N Barbera

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16 Citations (Web of Science)


In the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, encephalitogenic T cells differ from the non-encephalitogenic ones in their expression of CD49d. The disease-inducing CD49d(high) and not the CD49d(low) cells enter the brain parenchyma. In this context, we characterized CD4(+)(CD45RO(+))CD49d(high) cells in relapsing-remitting multiple sclerosis (RR-MS) patients. These cells, showing characteristics of activated cells able to produce pro-inflammatory cytokines, were found to be increased in peripheral blood during relapses and present in high numbers in cerebrospinal fluid. These results suggest that the CD4(+)CD45RO(+)CD49d(high) subpopulation in RR-MS patients includes autoreactive cells and may be target for immunotherapy. (C) 2000 Elsevier Science BN. All rights reserved.
Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - 1 Nov 2000


  • Cd4
  • CD49d
  • Cerebrospinal fluid
  • Cytokines
  • Multiple sclerosis
  • Relapse


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