CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo

Maria Angeles Carrillo-de Sauvage, Aurora Gómez, Carmen María Ros, Francisco Ros-Bernal, Eduardo D. Martín, Ana Perez-Vallés, José M. Gallego-Sanchez, Emiliano Fernández-Villalba, Carlos Barcia, Carlos Barcia, Maria Trinidad Herrero*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Abstract

CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in vivo remain elusive. Herein, we analyze the cell type that overexpresses CCL2 in multiple scenarios of T-cell infiltration in the brain and in three different species. We observe that CCL2 + astrocytes play a part in the infiltration of T-cells in the brain and our analysis shows that the contact of T-cells with perivascular astrocytes occurs, suggesting that may be an important event for lymphocyte extravasation.

Original languageEnglish
Article numbere30762
JournalPLoS ONE
Volume7
Issue number2
DOIs
Publication statusPublished - 2 Feb 2012

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