CCK is involved in both peripheral and central mechanisms controlling food intake in chickens

A. Rodríguez-Sinovas, E. Fernández, X. Manteca, A. G. Fernández, E. Goñalons

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    17 Citations (Scopus)

    Abstract

    The aim of this work was to study the involvement of cholecystokinin (CCK) in the control of food intake in chickens. The following aspects were studied: 1) the effects of intravenous and intracerebroventricular sulfated octapeptide of CCK (CCK-8s) on voluntary food intake; 2) the effects of two CCK-receptor antagonists, L-365,260 and L-364,718, on food intake; and 3) the ability of such drugs to block the effects of CCK-8s on food intake in the chicken. Intravenous and intracerebroventricular CCK-8s caused a decrease in food intake. Intraperitoneal L-365,260, a CCK-receptor antagonist with low affinity for the two CCK receptors described in the chicken, increases food intake. Intracerebroventricular L-364,718, a drug that has high affinity for the chicken central CCK-receptor type, increased food intake. The effect of intravenous CCK-8s on food intake was not blocked by L-364,718 or L-365,260, whereas that of intracerebroventricular CCK-8s was blocked by intracerebroventricular L-364,718. It is concluded that central endogenous CCK plays a role in the control of food intake, which is dependent on central CCK-receptor type; nevertheless, peripheral CCK also decreases food intake acting on the peripheral CCK-receptor type. The fact that intracerebroventricular L-364,718 is able to increase food intake is related to its high affinity for the central CCK-receptor type of this species. Finally, three different speculations that might explain the fact that intraperitoneal L-365,260 increases food intake are discussed.
    Original languageEnglish
    Pages (from-to)R334-R340
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Volume272
    Issue number1 41-1
    Publication statusPublished - 20 Feb 1997

    Keywords

    • cholecystokinin
    • L-364.718
    • L-365,260
    • satiety

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