Abstract
© 2019 by the authors. A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.
Original language | English |
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Article number | 1141 |
Journal | Molecules |
Volume | 24 |
DOIs | |
Publication status | Published - 1 Jan 2019 |
Keywords
- Enantioselectivity
- Europium
- Fluorination
- Keto ester
- Pybox