Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination

Albert Granados; Pau Sarró; Adelina Vallribera

doi:https://doi.org/10.3390/molecules24061141

Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination

Albert Granados, Pau Sarró, Adelina Vallribera

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4 Citations (Scopus)

Abstract

© 2019 by the authors. A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.

Original language	English
Article number	1141
Journal	Molecules
Volume	24
DOIs	https://doi.org/10.3390/molecules24061141
Publication status	Published - 1 Jan 2019

Keywords

Enantioselectivity
Europium
Fluorination
Keto ester
Pybox

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https://doi.org/10.3390/molecules24061141

https://ddd.uab.cat/record/223203

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title = "Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination",

abstract = "{\textcopyright} 2019 by the authors. A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.",

keywords = "Enantioselectivity, Europium, Fluorination, Keto ester, Pybox",

author = "Albert Granados and Pau Sarr{\'o} and Adelina Vallribera",

year = "2019",

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day = "1",

doi = "https://doi.org/10.3390/molecules24061141",

language = "English",

volume = "24",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination

AU - Granados, Albert

AU - Sarró, Pau

AU - Vallribera, Adelina

PY - 2019/1/1

Y1 - 2019/1/1

N2 - © 2019 by the authors. A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.

AB - © 2019 by the authors. A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.

KW - Enantioselectivity

KW - Europium

KW - Fluorination

KW - Keto ester

KW - Pybox

U2 - https://doi.org/10.3390/molecules24061141

DO - https://doi.org/10.3390/molecules24061141

M3 - Article

C2 - 30909403

VL - 24

JO - Molecules

JF - Molecules

SN - 1420-3049

M1 - 1141

ER -

Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination

Abstract

Keywords

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