Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination

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Abstract

© 2019 by the authors. A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.
Original languageEnglish
Article number1141
JournalMolecules
Volume24
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Enantioselectivity
  • Europium
  • Fluorination
  • Keto ester
  • Pybox

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