Catalase-peroxidase activity has no influence on virulence in a murine model of tuberculosis

Pere Joan Cardona, Sergi Gordillo, Isabel Amat, Jorge Díaz, Joan Lonca, Cristina Vilaplana, Angeles Pallarés, Roger Llatjós, Aurelio Ariza, Vicenç Ausina

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14 Citations (Scopus)

Abstract

The capacity to generate a chronic and persistent infection in the experimental murine model of tuberculosis induced aerogenically by a low-dose inoculum was determined in eight isoniazid-resistant clinical strains of Mycobacterium tuberculosis showing different catalase-peroxidase (C-P) activities. Determination of bacillary concentration in lung and spleen and the percentage of pulmonary parenchyma occupied by granulomas were monitored. Data showed no relation between the lack of C-P activity and the ability to develop a persistent infection, highlighting the potential of C-P negative strains to spread through the community. © 2003 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)351-359
JournalTuberculosis
Volume83
Issue number6
DOIs
Publication statusPublished - 1 Jan 2003

Keywords

  • Catalase-peroxidase
  • Isoniazid
  • Murine model
  • Tuberculosis
  • Virulence

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