Casein modified gold nanoparticles for future theranostic applications

Marisol Espinoza-Castañeda, Alfredo de la Escosura-Muñiz, Gemma González-Ortiz, Susana M. Martín-Orúe, José Francisco Pérez, Arben Merkoçi

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

The synthesis and characterization of gold nanoparticles (AuNPs 20. nm sized) modified with k-casein derived peptides in order to monitor the peptide effect as bacterial adhesion inhibitor, thanks to the carrier/concentrator effect of the AuNPs is here presented. Some aspects related to the stability of AuNP/peptide conjugates for a potential application in the design of an electrochemical biosensor for pathogen bacteria detection are also discussed. This peptide based nanoparticle assay takes advantage of the dual character of the AuNPs: as carrier of the biorecognition molecule and also as electrocatalytic label, allowing the evaluation of the pathogen bacteria-peptide interaction in a simple and rapid way through the chronoamperometric monitoring of the hydrogen evolution reaction on screen-printed carbon electrodes. The developed proof of concept theranostic system may open the way to therapeutic and biosensing applications with interest for various fields. © 2012 Elsevier B.V.
Original languageEnglish
Pages (from-to)271-276
JournalBiosensors and Bioelectronics
Volume40
Issue number1
DOIs
Publication statusPublished - 15 Feb 2013

Keywords

  • Bacteria
  • Biosensor
  • Caseinglycomacropeptide
  • Caseinglycopeptide
  • Gold nanoparticle
  • Hydrogen evolution electrocatalysis
  • Theranostic

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