Casein kinase 2 activity increases in the prereplicative phase of liver regeneration

Mercè Pérez, Jorge Grande, Emilio Itarte

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Cytosolic casein kinase activity increased up to 2-fold in the first 6 h after partial hepatectomy and then decreased to control values. This increase was due mainly to casein kinase 2, which reached maximal values at 6-8 h of liver regeneration. In contrast, casein kinase 1 showed a smaller increase at 4 h and then started to decrease reaching values of about 70% of control at 16 h. The increase in total casein kinase 2 was accompanied with an activation of the enzyme, as determined by the low/high β-casein activity ratio assay. Administration of an acute dose of glucagon to control rats also increased the activity ratio but failed to cause any rise in total casein kinase 2 activity. © 1988.
Original languageEnglish
Pages (from-to)273-276
JournalFEBS Letters
Volume238
Issue number2
DOIs
Publication statusPublished - 10 Oct 1988

Keywords

  • Casein kinase 2
  • Glucagon
  • Liver regeneration
  • Protein phosphorylation

Fingerprint Dive into the research topics of 'Casein kinase 2 activity increases in the prereplicative phase of liver regeneration'. Together they form a unique fingerprint.

Cite this