Cardiometabolic biomarkers in chronic plaque psoriasis before and after etanercept treatment

Lluís Puig, Robert Strohal, Joanne Fuiman, Ronald Pedersen, Annette Szumski, Andrew S. Koenig, Deborah Robertson, Heinz Drexel

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Objective: To assess cardiometabolic biomarkers in patients with psoriasis before and after etanercept treatment. Methods: Patients with moderate-to-severe plaque psoriasis were randomized to etanercept 50mg once or twice weekly, double-blinded. Cardiometabolic biomarkers were assessed at baseline and after 12 weeks of treatment (n=273). Results: At baseline, 42% of patients had metabolic syndrome. Etanercept was not associated with any clinically relevant adverse effects on cardiometabolic biomarkers. In the once-weekly subgroup, significant mean percentage changes from baseline (p<0.05) were observed for the quantitative insulin-sensitivity check index (QUICKI; -2.2%), apolipoprotein (Apo) A1 (3.2%), Apo B:Apo A1 ratio (-3.5%), leptin (8.6%) and high-sensitivity C-reactive protein (hsCRP) (-65.5%); and in the twice-weekly subgroup for plasma insulin (15.9%), QUICKI (-2.7%), high-density lipoprotein cholesterol (HDL-C; 2.9%), apolipoprotein (Apo) A1 (2.8%), Apo B:Apo A1 (-4.6%) and hsCRP (-74.4%). Conclusion: Metabolic syndrome was common in these patients with moderate-to-severe psoriasis. Etanercept treatment may provide some potentially favorable modulation of insulin sensitivity, HDL-C, Apo A1 and Apo B:Apo A1 ratio. © 2014 Informa UK Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)470-481
JournalJournal of Dermatological Treatment
Volume25
Issue number6
DOIs
Publication statusPublished - 1 Dec 2014

Keywords

  • Cardiovascular risk
  • Comorbidities
  • Etanercept
  • Metabolic syndrome
  • Psoriasis
  • Treatment

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