Cardioembolic stroke diagnosis using blood biomarkers

Víctor Llombart, Teresa García-Berrocoso, Alejandro Bustamante, Israel Fernández-Cadenas, Joan Montaner

    Research output: Contribution to journalArticleResearchpeer-review

    16 Citations (Scopus)

    Abstract

    Stroke is one of the main causes of death and disability in the world. Cardioembolic etiology accounts for approximately one fifth of all ischemic strokes whereas 25-30% remains undetermined even after an advanced diagnostic workup. Despite there is not any biomarker currently approved to distinguish cardioembolic stroke among other etiologies in clinical practice the use of biomarkers represents a promising valuable complement to determine stroke etiology reducing the number of cryptogenic strokes and aiding in the prescription of the most appropriated primary and secondary treatments in order to minimize therapeutic risks and to avoid recurrences. In this review we present an update about specific cardioembolic stroke-related biomarkers at a protein, transcriptomic and genetic level. Finally, we also focused on reported biomarkers associated with atrial fibrillation (a cardiac illness strongly related with cardioembolic stroke subtype) thus with a potential to become biomarkers to detect cardioembolic stroke in the future. © 2013 Bentham Science Publishers.
    Original languageEnglish
    Pages (from-to)340-352
    JournalCurrent Cardiology Reviews
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - 1 Jan 2013

    Keywords

    • Atrial
    • Biomarker
    • Cardioembolic
    • Classification
    • Etiology
    • Fibrillation
    • MiRNA
    • Stroke

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