Cardiac tissue engineering and the bioartificial heart

Carolina Gálvez-Montón, Cristina Prat-Vidal, Santiago Roura, Carolina Soler-Botija, Antoni Bayes-Genis

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Abstract

Heart failure is the end-stage of many cardiovascular diseases - such as acute myocardial infarction - and remains one of the most appealing challenges for regenerative medicine because of its high incidence and prevalence. Over the last 20 years, cardiomyoplasty, based on the isolated administration of cells with regenerative capacity, has been the focal point of most studies aimed at regenerating the heart. Although this therapy has proved feasible in the clinical setting, the degree of infarcted myocardium regenerated and of improved cardiac function are at best modest. Hence, tissue engineering has emerged as a novel technology using cells with regenerative capacity, biological and/or synthetic materials, growth, proangiogenic and differentiation factors, and online registry systems, to induce the regeneration of whole organs or locally damaged tissue. The next step, seen recently in pioneering animal studies, is de novo generation of bioartificial hearts by decellularization and preservation of supporting structures for their subsequent repopulation with new contractile, vascular muscle tissue. Ultimately, this new approach would entail transplantation of the «rebuilt» heart, reestablishing cardiac function in the recipient. © 2012 Sociedad Española de Cardiología. Publicado por Elsevier España, S.L. Todos los derechos reservados.
Original languageEnglish
Pages (from-to)391-399
JournalRevista Espanola de Cardiologia
Volume66
Issue number5
DOIs
Publication statusPublished - 1 May 2013

Keywords

  • Cardiac regeneration
  • Cardiac tissue engineering
  • Cardiomioplasty
  • Neo-organogenesis

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