Cardiac adipose tissue: A new frontier for cardiac regeneration?

Antoni Bayes-Genis, Carolina Gálvez-Montón, Cristina Prat-Vidal, Carolina Soler-Botija

Research output: Contribution to journalReview articleResearchpeer-review

21 Citations (Scopus)

Abstract

The human heart has limited regenerative capacity. We focused on cardiac adipose tissue as a source of progenitor cells and biological matrix material for salvaging injured myocardium. First, a population of human adult mesenchymal-like progenitors derived from cardiac adipose tissue, with inherent cardiac and endothelial cell potential, was identified and characterized. Next, a salvage strategy was tested, where a pericardial-derived, vascularized, adipose flap was used to cover oxygen-deprived myocardium in a porcine model. The fat flap reduced the myocardial scar size, in both acute and chronic infarcts. A human clinical trial to examine this novel intervention is currently underway. © 2012 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)22-25
JournalInternational Journal of Cardiology
Volume167
Issue number1
DOIs
Publication statusPublished - 15 Jul 2013

Keywords

  • Adipose flap
  • Cardiac regeneration
  • Myocardial infarction

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