Carboxyl group (-CO<inf>2</inf>H) functionalized coordination polymer nanoparticles as efficient platforms for drug delivery

Fernando Novio, Julia Lorenzo, Fabiana Nador, Karolina Wnuk, Daniel Ruiz-Molina

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Functionalization of nanoparticles can significantly influence their properties and potential applications. Although researchers can now functionalize metal, metal oxide, and organic polymer nanoparticles with a high degree of precision, controlled surface functionalization of nanoscale coordination polymer particles (CPPs) has remained a significant challenge. The lack of methodology is perhaps one of the greatest roadblocks to the advancement of CPPs into high added-value drug delivery applications. Here, we report having achieved this goal through a stepwise formation and functionalization protocol. We fabricated robust nanoparticles with enhanced thermal and colloidal stabilities by incorporation of carboxyl groups and these surface carboxyl groups could be subsequently functionalized through well-known peptide coupling reactions. The set of chemistries that we employed as proof-of-concept enabled a plethora of new functional improvements for the application of CPPs as drug delivery carriers, including enhanced colloidal stabilities and the incorporation of additional functional groups such as polyethylene glycol (PEG) or fluorescent dyes that enabled tracking of their cellular uptake. Finally, we ascertained the cytotoxicity of the new CPP nanoparticles loaded with camptothecin to human breast adenocarcinoma (MCF-7). Efflux measurements show that the encapsulation of camptothecin enhances the potency of the drug 6.5-fold and increases the drug retention within the cell. Multifunctional CPPs: Robust and biocompatible coordination polymer nanoparticles (CPPs) with enhanced thermal and colloidal stabilities were obtained by incorporation of carboxyl groups on the amorphous structure. The surface carboxyl groups can be subsequently functionalized, generating a multifunctional nanoplatform for theranostic applications such as drug delivery and imaging (see scheme; EDC=1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; NHS=N-hydroxysuccinimide).
Original languageEnglish
Pages (from-to)15443-15450
JournalChemistry - A European Journal
Volume20
Issue number47
DOIs
Publication statusPublished - 1 Nov 2014

Keywords

  • catechol
  • coordination polymers
  • drug delivery
  • nanoparticles
  • surface functionalization

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