Carbon Multiplicity Editing in Long-Range Heteronuclear Correlation NMR Experiments: A Valuable Tool for the Structure Elucidation of Natural Products

Josep Saurí, Michel Frédérich, Alembert T. Tchinda, Teodor Parella, R. Thomas Williamson, Gary E. Martin

    Research output: Contribution to journalArticleResearchpeer-review

    8 Citations (Scopus)

    Abstract

    © 2015 The American Chemical Society and American Society of Pharmacognosy. A recently developed NMR method to simultaneously obtain both long-range heteronuclear correlations and carbon multiplicity information in a single experiment, ME-selHSQMBC, is demonstrated as a potentially useful technique for chemical shift assignment and structure elucidation of natural products presenting complicated NMR spectra. Carbon multiplicities, even for C/CH2 and odd for CH/CH3 resonances, can be distinguished directly from the relative positive/negative phase of cross-peaks. In addition, connectivity networks can be further extended by incorporating a TOCSY propagation step. Staurosporine (1) and sungucine (2) are utilized as model compounds to demonstrate these techniques.
    Original languageEnglish
    Pages (from-to)2236-2241
    JournalJournal of Natural Products
    Volume78
    Issue number9
    DOIs
    Publication statusPublished - 25 Sep 2015

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