TY - JOUR
T1 - Carbon Multiplicity Editing in Long-Range Heteronuclear Correlation NMR Experiments: A Valuable Tool for the Structure Elucidation of Natural Products
AU - Saurí, Josep
AU - Frédérich, Michel
AU - Tchinda, Alembert T.
AU - Parella, Teodor
AU - Williamson, R. Thomas
AU - Martin, Gary E.
PY - 2015/9/25
Y1 - 2015/9/25
N2 - © 2015 The American Chemical Society and American Society of Pharmacognosy. A recently developed NMR method to simultaneously obtain both long-range heteronuclear correlations and carbon multiplicity information in a single experiment, ME-selHSQMBC, is demonstrated as a potentially useful technique for chemical shift assignment and structure elucidation of natural products presenting complicated NMR spectra. Carbon multiplicities, even for C/CH2 and odd for CH/CH3 resonances, can be distinguished directly from the relative positive/negative phase of cross-peaks. In addition, connectivity networks can be further extended by incorporating a TOCSY propagation step. Staurosporine (1) and sungucine (2) are utilized as model compounds to demonstrate these techniques.
AB - © 2015 The American Chemical Society and American Society of Pharmacognosy. A recently developed NMR method to simultaneously obtain both long-range heteronuclear correlations and carbon multiplicity information in a single experiment, ME-selHSQMBC, is demonstrated as a potentially useful technique for chemical shift assignment and structure elucidation of natural products presenting complicated NMR spectra. Carbon multiplicities, even for C/CH2 and odd for CH/CH3 resonances, can be distinguished directly from the relative positive/negative phase of cross-peaks. In addition, connectivity networks can be further extended by incorporating a TOCSY propagation step. Staurosporine (1) and sungucine (2) are utilized as model compounds to demonstrate these techniques.
U2 - 10.1021/acs.jnatprod.5b00447
DO - 10.1021/acs.jnatprod.5b00447
M3 - Article
VL - 78
SP - 2236
EP - 2241
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 9
ER -